Doctor of Biology, Associate Professor Gurbanova Inna Musa

Basic activity directions

Photosynthesis. Damages and adaptation  mechanisms of photosystems;
Damaging factors of the stress processes: high temperature, salinity, heavy metals Al3+, Mn2+, Cd2+, Co2+, Ni2+, Zn2+, Cu2+) act on plant durability. Research of the cell and molecular mechanisms of these processes;
The study of the stability and adaptation properties of the membrane system of chloroplasts with the help of  some protectors and stabilizators;
Investigation of the physical and chemical properties and regulation of mechanism of sensitive macrolactone compounds to membranes.

Main scientific achievements

The effect of Cu2+ on the state of the pigment fond in chloroplasts was studied at all pH of the medium during 24, 48 and 72 hours of exposure. As protectors, sage leaves (Folia Salvia officinalis), liquorice root (Radix glycyrrhizae) and leaves of the relict plant Danae racemosa were used, the activity of which depended on the time of exposure. The results of the study of infra-red spectra indicate that the extracts used have phenolic compounds, namely, OH groups associated with valence vibrations of aromatic (C-C) bonds protect the pigments from oxidative stress. In comparison with extracts of sage and liquorice roots, the flavonoids present in the composition, the biologically active composition (BAC) based on plumbagin and to a greater extent Na-ascorbate neutralizes reactive oxygen species, maintaining the balance between redox reactions in the electron transport chain of photosystem 2 (ETC FS 2). As shown by the fluorescent characteristics of millisecond delayed fluorescence of chlorophyll a (msec DF Chl a) damage with methylviologene (MV), photosystem 2 (FS 2) is restored by Na-ascorbate. The reaction of primary charge separation on the donor side of the ETC electron transfer to the primary quinone acceptor QA is restored. It has been shown that a violation of D1 de novo protein synthesis inactivates the reaction center (RC) of FS 2 and damages the synthesis of new centers. This leads to changes in the fluorescent properties. PAAG electrophoresis revealed that depending on the action of methylviologen and chloramphenicol, it leads to a change in the protein spectrum. It was shown that the interaction of proteins between the correlation changes and the state of ETC occurs with an increase in the stationary level on the induction curve of msec DF Chl a.
The main purpose of the research is to study the mechanism of assembly and disassembly of polyene channels  in lipid membranes, using certain structures of polyene antibiotics (PA). There were researched molecular dynamics and physical and chemical characteristics of these antibiotics and their derivatives in our laboratory. In this way polyene antibiotics and their derivatives play major role in the action of proliferation process of clonogenic cells. Among them, levorin and metillevorin stopped this process on Hela and S6 cell cultures. For the first time, 70% of the inhibition of the process of proliferation of clonogenic tumor cells by levorin A and its derivatives was observed. These results are very important in medicine and lead to the search of new anticancer drugs. Results are printed in different scientific journals. Also there are researched the action of amphotericin and levorin on different bacterial and fungal strains  in cell cultures. This work is continued by the scientists in the laboratory.

Total number of employees 9
Phone (+99412) 538 15 70